St. John's wort interactions
Overview
St. John's wort is an herbal supplement for mood. In our database it has 29 known interactions with common medicines and substances: 8 serious, 21 that need caution and 0 minor.
Avoid / serious 8 interactions
Can make your medicine stop workingAtorvastatin
Can make your medicine stop workingBirth control pills
Can make your medicine stop workingEstradiol
Can make your medicine stop workingPaxlovid
Can make your medicine stop workingRivaroxaban
Can make your medicine stop workingSimvastatin
Can make your medicine stop workingWarfarin
Can make your medicine stop working
Use caution 21 interactions
Serotonin syndrome riskAmphetamine salts
Serotonin syndrome riskBuspirone
Serotonin syndrome riskCitalopram
Serotonin syndrome riskCyclobenzaprine
Serotonin syndrome riskDayQuil
Serotonin syndrome riskDextromethorphan
Serotonin syndrome riskDuloxetine
Serotonin syndrome riskEscitalopram
Serotonin syndrome riskFluoxetine
Serotonin syndrome riskLisdexamfetamine
Serotonin syndrome riskLithium
Serotonin syndrome riskMirtazapine
Serotonin syndrome riskNyQuil
Serotonin syndrome riskOndansetron
Serotonin syndrome riskParoxetine
Serotonin syndrome riskSertraline
Serotonin syndrome riskSumatriptan
Serotonin syndrome riskTramadol
Serotonin syndrome riskTrazodone
Serotonin syndrome riskVenlafaxine
Serotonin syndrome risk
No known interaction found
Our rules found no interaction between St. John's wort and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Azithromycin, Baclofen, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Empagliflozin, Esomeprazole, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisinopril, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Oseltamivir, Oxycodone, Pantoprazole, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rosuvastatin, Semaglutide, Sildenafil, Spironolactone, Sulfamethoxazole-trimethoprim, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Turmeric, Valacyclovir, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
There is no single FDA label for this item, so interactions listed here come from the FDA labels of the medicines it interacts with, and from NIH guidance where noted.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.