Gabapentin interactions
Overview
Gabapentin (Neurontin) is a nerve pain and seizure medicine. In our database it has 33 known interactions with common medicines and substances: 7 serious, 24 that need caution and 2 minor.
Avoid / serious 7 interactions
Serious breathing problemsCodeine
Serious breathing problemsHydrocodone
Serious breathing problemsKratom
Serious breathing problemsMorphine
Serious breathing problemsOxycodone
Serious breathing problemsTramadol
Serious breathing problems
Use caution 24 interactions
Alcohol adds to drowsiness and dizzinessAlprazolam
Extra drowsiness and slowed reactionsAmitriptyline
Combined drowsinessBaclofen
Combined drowsinessCannabis
Combined drowsinessClonazepam
Extra drowsiness and slowed reactionsClonidine
Combined drowsinessCyclobenzaprine
Combined drowsinessDiazepam
Extra drowsiness and slowed reactionsDiphenhydramine
Combined drowsinessDoxylamine
Combined drowsinessHydroxyzine
Combined drowsinessLevetiracetam
Combined drowsinessLorazepam
Extra drowsiness and slowed reactionsMeclizine
Combined drowsinessMethocarbamol
Combined drowsinessMirtazapine
Combined drowsinessNyQuil
Combined drowsinessPregabalin
Combined drowsinessPromethazine
Combined drowsinessQuetiapine
Combined drowsinessTizanidine
Combined drowsinessTrazodone
Combined drowsinessZolpidem
Extra drowsiness and slowed reactions
Minor 2 interactions
In-depth guides
No known interaction found
Our rules found no interaction between Gabapentin and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Aspirin, Atenolol, Atorvastatin, Azithromycin, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clopidogrel, Colchicine, Creatine, DayQuil, Dextromethorphan, Diclofenac, Digoxin, Doxycycline, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Losartan, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Gabapentin on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.