Bupropion interactions
Overview
Bupropion (Wellbutrin, Zyban) is an antidepressant and quit-smoking aid. In our database it has 22 known interactions with common medicines and substances: 0 serious, 22 that need caution and 0 minor.
Use caution 22 interactions
Alcohol and seizure riskAmitriptyline
Higher seizure riskAmphetamine salts
Higher seizure riskAripiprazole
Can change levels of the other medicineCarvedilol
Can change levels of the other medicineCitalopram
Can change levels of the other medicineCodeine
Can change levels of the other medicineDuloxetine
Can change levels of the other medicineEscitalopram
Can change levels of the other medicineFluoxetine
Can change levels of the other medicineHydrocodone
Can change levels of the other medicineLisdexamfetamine
Higher seizure riskMethylphenidate
Higher seizure riskMethylprednisolone
Higher seizure riskMetoprolol
Can change levels of the other medicineParoxetine
Can change levels of the other medicinePhentermine
Higher seizure riskPrednisone
Higher seizure riskPropranolol
Can change levels of the other medicineSertraline
Can change levels of the other medicineTramadol
Higher seizure riskVenlafaxine
Can change levels of the other medicine
In-depth guides
No known interaction found
Our rules found no interaction between Bupropion and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Apixaban, Ashwagandha, Aspirin, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Buspirone, Caffeine, Calcium carbonate, Cannabis, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Empagliflozin, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Hydroxyzine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paxlovid, Phenylephrine, Potassium supplements, Pravastatin, Pregabalin, Probiotics, Promethazine, Pseudoephedrine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Trazodone, Turmeric, Valacyclovir, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Bupropion on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.