Aspirin interactions
Overview
Aspirin (Bayer, Ecotrin) is an NSAID pain reliever that also thins the blood. In our database it has 31 known interactions with common medicines and substances: 5 serious, 26 that need caution and 0 minor.
Avoid / serious 5 interactions
Higher risk of serious bleedingLithium
Can raise lithium to toxic levelsMethotrexate
Can raise methotrexate to dangerous levelsRivaroxaban
Higher risk of serious bleedingWarfarin
Higher risk of serious bleeding
Use caution 26 interactions
Stomach bleeding riskBismuth subsalicylate
Pepto-Bismol contains a salicylate (aspirin-like)Celecoxib
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionCitalopram
Higher bleeding riskClopidogrel
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionDiclofenac
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionDuloxetine
Higher bleeding riskEmpagliflozin
Can strain the kidneys and weaken blood pressure controlEscitalopram
Higher bleeding riskExcedrin
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionFish oil
May add to bleeding riskFluoxetine
Higher bleeding riskFurosemide
Can strain the kidneys and weaken blood pressure controlHydrochlorothiazide
Can strain the kidneys and weaken blood pressure controlIbuprofen
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionLisinopril
Can strain the kidneys and weaken blood pressure controlLosartan
Can strain the kidneys and weaken blood pressure controlMeloxicam
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionMethylprednisolone
Higher risk of stomach ulcers and bleedingNaproxen
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionParoxetine
Higher bleeding riskPrednisone
Higher risk of stomach ulcers and bleedingSertraline
Higher bleeding riskSpironolactone
Can strain the kidneys and weaken blood pressure controlTurmeric
May add to bleeding riskVenlafaxine
Higher bleeding risk
No known interaction found
Our rules found no interaction between Aspirin and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Aripiprazole, Ashwagandha, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clonidine, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fluconazole, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Loperamide, Loratadine, Lorazepam, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methylphenidate, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Trazodone, Valacyclovir, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Aspirin on DailyMed (effective 2026-08), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.