Melatonin interactions
Overview
Melatonin is a sleep hormone sold as a supplement. In our database it has 32 known interactions with common medicines and substances: 0 serious, 0 that need caution and 32 minor.
Minor 32 interactions
A bit more drowsinessAlprazolam
A bit more drowsinessAmitriptyline
A bit more drowsinessBaclofen
A bit more drowsinessBuprenorphine-naloxone
A bit more drowsinessCannabis
A bit more drowsinessClonazepam
A bit more drowsinessClonidine
A bit more drowsinessCodeine
A bit more drowsinessCyclobenzaprine
A bit more drowsinessDiazepam
A bit more drowsinessDiphenhydramine
A bit more drowsinessDoxylamine
A bit more drowsinessGabapentin
A bit more drowsinessHydrocodone
A bit more drowsinessHydroxyzine
A bit more drowsinessKratom
A bit more drowsinessLevetiracetam
A bit more drowsinessLorazepam
A bit more drowsinessMeclizine
A bit more drowsinessMethocarbamol
A bit more drowsinessMirtazapine
A bit more drowsinessMorphine
A bit more drowsinessNyQuil
A bit more drowsinessOxycodone
A bit more drowsinessPregabalin
A bit more drowsinessPromethazine
A bit more drowsinessQuetiapine
A bit more drowsinessTizanidine
A bit more drowsinessTramadol
A bit more drowsinessTrazodone
A bit more drowsinessZolpidem
A bit more drowsiness
No known interaction found
Our rules found no interaction between Melatonin and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Atorvastatin, Azithromycin, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clopidogrel, Colchicine, Creatine, DayQuil, Dextromethorphan, Diclofenac, Digoxin, Doxycycline, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Losartan, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
There is no single FDA label for this item, so interactions listed here come from the FDA labels of the medicines it interacts with, and from NIH guidance where noted.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.