Zolpidem interactions

Updated October 4, 2026How we check

Overview

Zolpidem (Ambien) is a prescription sleep medicine. In our database it has 34 known interactions with common medicines and substances: 9 serious, 23 that need caution and 2 minor.

Avoid / serious 9 interactions

Alcohol
Alcohol greatly increases sedation Buprenorphine-naloxone
Too much sedation and slowed breathing Codeine
Too much sedation and slowed breathing Hydrocodone
Too much sedation and slowed breathing Kratom
Too much sedation and slowed breathing Morphine
Too much sedation and slowed breathing Oxycodone
Too much sedation and slowed breathing Paxlovid
Paxlovid can raise this medicine to unsafe levels Tramadol
Too much sedation and slowed breathing

Use caution 23 interactions

Minor 2 interactions

Ashwagandha
A bit more drowsiness Melatonin
A bit more drowsiness

No known interaction found

Our rules found no interaction between Zolpidem and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Aspirin, Atenolol, Atorvastatin, Azithromycin, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clopidogrel, Colchicine, Creatine, DayQuil, Dextromethorphan, Diclofenac, Digoxin, Doxycycline, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Losartan, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paroxetine, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc.

Check Zolpidem with your other medicines

Add at least two medicines, supplements or alcohol.

Try: Advil + Tylenol · Zoloft + Advil · Flagyl + alcohol

Sources

Source: FDA label for Zolpidem on DailyMed (effective 2026-09), plus the labels of each interacting medicine.

This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.