Rivaroxaban interactions
Overview
Rivaroxaban (Xarelto) is a blood thinner (anticoagulant). In our database it has 22 known interactions with common medicines and substances: 13 serious, 9 that need caution and 0 minor.
Avoid / serious 13 interactions
Two anticoagulants at onceAspirin
Higher risk of serious bleedingBismuth subsalicylate
Higher risk of serious bleedingCelecoxib
Higher risk of serious bleedingClopidogrel
Two types of blood thinnerDiclofenac
Higher risk of serious bleedingExcedrin
Higher risk of serious bleedingIbuprofen
Higher risk of serious bleedingMeloxicam
Higher risk of serious bleedingNaproxen
Higher risk of serious bleedingPaxlovid
Paxlovid can raise this medicine to unsafe levelsSt. John's wort
Can make your medicine stop workingWarfarin
Two anticoagulants at once
Use caution 9 interactions
Higher bleeding riskDuloxetine
Higher bleeding riskEscitalopram
Higher bleeding riskFish oil
May add to bleeding riskFluoxetine
Higher bleeding riskParoxetine
Higher bleeding riskSertraline
Higher bleeding riskTurmeric
May add to bleeding riskVenlafaxine
Higher bleeding risk
No known interaction found
Our rules found no interaction between Rivaroxaban and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Aripiprazole, Ashwagandha, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clonidine, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Empagliflozin, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fluconazole, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Trazodone, Valacyclovir, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Rivaroxaban on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.