Metoprolol interactions
Overview
Metoprolol (Lopressor, Toprol XL) is a beta blocker for blood pressure and heart rate. In our database it has 21 known interactions with common medicines and substances: 0 serious, 8 that need caution and 13 minor.
Use caution 8 interactions
Beta blockers can block your rescue inhalerBupropion
Can change levels of the other medicineClonidine
Slow heart rate and heart block riskDayQuil
Can raise blood pressure and heart rateFluoxetine
Can change levels of the other medicineParoxetine
Can change levels of the other medicinePhenylephrine
Can raise blood pressure and heart ratePseudoephedrine
Can raise blood pressure and heart rate
Minor 13 interactions
Additive blood pressure loweringAtenolol
Additive blood pressure loweringCarvedilol
Additive blood pressure loweringFurosemide
Additive blood pressure loweringHydrochlorothiazide
Additive blood pressure loweringLisinopril
Additive blood pressure loweringLosartan
Additive blood pressure loweringPropranolol
Additive blood pressure loweringSildenafil
Small extra drop in blood pressureSpironolactone
Additive blood pressure loweringTadalafil
Small extra drop in blood pressureTamsulosin
Additive blood pressure loweringTizanidine
Additive blood pressure lowering
No known interaction found
Our rules found no interaction between Metoprolol and: Acetaminophen, Acyclovir, Alcohol, Allopurinol, Alprazolam, Amitriptyline, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Buspirone, Caffeine, Calcium carbonate, Cannabis, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clonazepam, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, Dextromethorphan, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lithium, Loperamide, Loratadine, Lorazepam, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paxlovid, Phentermine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Simvastatin, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tirzepatide, Topiramate, Tramadol, Trazodone, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Metoprolol on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.