Sertraline interactions
Also sold as Zoloft
Sertraline is an SSRI antidepressant. Below is every interaction with the 147 medicines and substances in our database, grouped by how serious it is.
FDA boxed warning
Suicidal Thoughts and Behaviors“Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors.”
Read the full label on DailyMed →A boxed warning is the FDA’s strongest label warning. It is about the medicine itself, not a specific interaction.
Avoid / serious
6Avoid or use only under close supervision.
Two antidepressants that raise serotonin
6 drugsTaking two SSRI or SNRI antidepressants together greatly raises the risk of serotonin syndrome, which can cause agitation, fast heartbeat, high temperature, muscle twitching and, in severe cases, death.
Use caution
34Often used together with precautions.
Serotonin syndrome risk
14 drugsBoth medicines increase serotonin activity. The combination is often used safely, but it can occasionally cause serotonin syndrome: agitation, sweating, fast heartbeat, fever, muscle twitching or stiffness.
Higher bleeding risk
12 drugsSSRI and SNRI antidepressants affect how platelets work. Taken with NSAIDs, aspirin or blood thinners, they raise the risk of bleeding, including stomach bleeding and easy bruising.
Serotonin syndrome and seizure risk
6 drugsSome opioids, especially tramadol, raise serotonin. With antidepressants this can lead to serotonin syndrome, and tramadol with some antidepressants also raises seizure risk. Some antidepressants can also make tramadol and codeine less effective.
Alcohol can worsen side effects and mood
1 drugAlcohol can add drowsiness and dizziness, and it can worsen depression, hopelessness or seizure control. Antidepressant labels advise against drinking during treatment, and with some, such as duloxetine, heavy drinking is linked to liver injury.
Can change levels of the other medicine
1 drugThis antidepressant strongly blocks the liver enzyme CYP2D6. It can raise levels of medicines cleared by that enzyme, or stop prodrugs like codeine and tramadol from turning into their active form.
Common questions about Sertraline
Can you take sertraline (Zoloft) with bupropion (Wellbutrin)?Use caution
Use caution: Can change levels of the other medicine. This antidepressant strongly blocks the liver enzyme CYP2D6. It can raise levels of medicines cleared by that enzyme, or stop prodrugs like codeine and tramadol from turning into their active form. What to do: Your prescriber may adjust doses. Report increased side effects, or reduced pain relief with codeine or tramadol.
Can you drink alcohol while taking sertraline (Zoloft)?Use caution
Use caution: Alcohol can worsen side effects and mood. Alcohol can add drowsiness and dizziness, and it can worsen depression, hopelessness or seizure control. Antidepressant labels advise against drinking during treatment, and with some, such as duloxetine, heavy drinking is linked to liver injury. What to do: Avoid alcohol or keep it minimal, and do not drive if you feel impaired.
Can you take sertraline (Zoloft) with ibuprofen (Advil)?Use caution
Use caution: Higher bleeding risk. SSRI and SNRI antidepressants affect how platelets work. Taken with NSAIDs, aspirin or blood thinners, they raise the risk of bleeding, including stomach bleeding and easy bruising. What to do: Occasional use is often acceptable, but ask your doctor about regular use. Report black stools, vomiting blood or unusual bruising.
Can you take sertraline (Zoloft) with cannabis (marijuana)?No known interaction
No interaction between sertraline and cannabis was found in FDA labeling or our rules. That is reassuring but not a guarantee, so check with your pharmacist about your doses and health conditions.
Can you take sertraline (Zoloft) with amphetamine salts (Adderall)?Use caution
Use caution: Serotonin syndrome risk. Both medicines increase serotonin activity. The combination is often used safely, but it can occasionally cause serotonin syndrome: agitation, sweating, fast heartbeat, fever, muscle twitching or stiffness. What to do: Do not stop either medicine on your own. Tell your prescriber about both and seek care for the symptoms above.
Can you take sertraline (Zoloft) with hydroxyzine (Atarax)?No known interaction
No interaction between sertraline and hydroxyzine was found in FDA labeling or our rules. That is reassuring but not a guarantee, so check with your pharmacist about your doses and health conditions.
No known interaction with 106 other medicines and substances Show list
Sources
FDA label for Sertraline (effective 2026-08): view on DailyMed. Each interaction above is based on the labels of both medicines; open any one to see the exact label wording.
This list covers the 147 medicines and substances in our database and is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.