Clopidogrel interactions
Overview
Clopidogrel (Plavix) is an antiplatelet blood thinner. In our database it has 21 known interactions with common medicines and substances: 3 serious, 18 that need caution and 0 minor.
Avoid / serious 3 interactions
Two types of blood thinnerRivaroxaban
Two types of blood thinnerWarfarin
Two types of blood thinner
Use caution 18 interactions
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionCelecoxib
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionCitalopram
Higher bleeding riskDiclofenac
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionDuloxetine
Higher bleeding riskEscitalopram
Higher bleeding riskEsomeprazole
Can make clopidogrel less effectiveExcedrin
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionFish oil
May add to bleeding riskFluoxetine
Higher bleeding riskIbuprofen
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionMeloxicam
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionNaproxen
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionOmeprazole
Can make clopidogrel less effectiveParoxetine
Higher bleeding riskSertraline
Higher bleeding riskTurmeric
May add to bleeding riskVenlafaxine
Higher bleeding risk
No known interaction found
Our rules found no interaction between Clopidogrel and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Aripiprazole, Ashwagandha, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clonidine, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Empagliflozin, Estradiol, Famotidine, Fexofenadine, Finasteride, Fluconazole, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, NyQuil, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Trazodone, Valacyclovir, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Clopidogrel on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.