Fluoxetine interactions
Overview
Fluoxetine (Prozac) is an SSRI antidepressant. In our database it has 51 known interactions with common medicines and substances: 6 serious, 45 that need caution and 0 minor.
Avoid / serious 6 interactions
Two antidepressants that raise serotoninDuloxetine
Two antidepressants that raise serotoninEscitalopram
Two antidepressants that raise serotoninParoxetine
Two antidepressants that raise serotoninSertraline
Two antidepressants that raise serotoninVenlafaxine
Two antidepressants that raise serotonin
Use caution 45 interactions
Alcohol can worsen side effects and moodAmitriptyline
Serotonin syndrome riskAmphetamine salts
Serotonin syndrome riskApixaban
Higher bleeding riskAripiprazole
Can change levels of the other medicineAspirin
Higher bleeding riskAzithromycin
Heart rhythm (QT) riskBismuth subsalicylate
Higher bleeding riskBuprenorphine-naloxone
Serotonin syndrome and seizure riskBupropion
Can change levels of the other medicineBuspirone
Serotonin syndrome riskCarvedilol
Can change levels of the other medicineCelecoxib
Higher bleeding riskCiprofloxacin
Heart rhythm (QT) riskClopidogrel
Higher bleeding riskCodeine
Serotonin syndrome and seizure riskCyclobenzaprine
Serotonin syndrome riskDayQuil
Serotonin syndrome riskDextromethorphan
Serotonin syndrome riskDiclofenac
Higher bleeding riskExcedrin
Higher bleeding riskFluconazole
Heart rhythm (QT) riskHydrocodone
Serotonin syndrome and seizure riskHydroxychloroquine
Heart rhythm (QT) riskHydroxyzine
Heart rhythm (QT) riskIbuprofen
Higher bleeding riskLevofloxacin
Heart rhythm (QT) riskLisdexamfetamine
Serotonin syndrome riskLithium
Serotonin syndrome riskMeloxicam
Higher bleeding riskMetoprolol
Can change levels of the other medicineMirtazapine
Serotonin syndrome riskMorphine
Serotonin syndrome and seizure riskNaproxen
Higher bleeding riskNyQuil
Serotonin syndrome riskOndansetron
Serotonin syndrome riskOxycodone
Serotonin syndrome and seizure riskPropranolol
Can change levels of the other medicineQuetiapine
Heart rhythm (QT) riskRivaroxaban
Higher bleeding riskSt. John's wort
Serotonin syndrome riskSumatriptan
Serotonin syndrome riskTramadol
Serotonin syndrome and seizure riskTrazodone
Serotonin syndrome riskWarfarin
Higher bleeding risk
No known interaction found
Our rules found no interaction between Fluoxetine and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Ashwagandha, Atenolol, Atorvastatin, Baclofen, Birth control pills, Caffeine, Calcium carbonate, Cannabis, Cephalexin, Cetirizine, Clindamycin, Clonazepam, Clonidine, Colchicine, Creatine, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Empagliflozin, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levothyroxine, Lisinopril, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metronidazole, Montelukast, Naltrexone, Nicotine, Nitrofurantoin, Omeprazole, Oseltamivir, Pantoprazole, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Pseudoephedrine, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, Sulfamethoxazole-trimethoprim, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Turmeric, Valacyclovir, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Fluoxetine on DailyMed (effective 2026-08), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.