Naproxen interactions
Overview
Naproxen (Aleve) is an NSAID pain reliever. In our database it has 29 known interactions with common medicines and substances: 5 serious, 24 that need caution and 0 minor.
Avoid / serious 5 interactions
Higher risk of serious bleedingLithium
Can raise lithium to toxic levelsMethotrexate
Can raise methotrexate to dangerous levelsRivaroxaban
Higher risk of serious bleedingWarfarin
Higher risk of serious bleeding
Use caution 24 interactions
Stomach bleeding riskAspirin
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionBismuth subsalicylate
Pepto-Bismol contains a salicylate (aspirin-like)Celecoxib
Two NSAIDs at onceCitalopram
Higher bleeding riskClopidogrel
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionDiclofenac
Two NSAIDs at onceDuloxetine
Higher bleeding riskEmpagliflozin
Can strain the kidneys and weaken blood pressure controlEscitalopram
Higher bleeding riskExcedrin
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionFluoxetine
Higher bleeding riskFurosemide
Can strain the kidneys and weaken blood pressure controlHydrochlorothiazide
Can strain the kidneys and weaken blood pressure controlIbuprofen
Two NSAIDs at onceLisinopril
Can strain the kidneys and weaken blood pressure controlLosartan
Can strain the kidneys and weaken blood pressure controlMeloxicam
Two NSAIDs at onceMethylprednisolone
Higher risk of stomach ulcers and bleedingParoxetine
Higher bleeding riskPrednisone
Higher risk of stomach ulcers and bleedingSertraline
Higher bleeding riskSpironolactone
Can strain the kidneys and weaken blood pressure controlVenlafaxine
Higher bleeding risk
In-depth guides
No known interaction found
Our rules found no interaction between Naproxen and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Aripiprazole, Ashwagandha, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clonidine, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Loperamide, Loratadine, Lorazepam, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methylphenidate, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Trazodone, Turmeric, Valacyclovir, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Naproxen on DailyMed (effective 2026-08), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.