Dextromethorphan interactions
Overview
Dextromethorphan (Robitussin DM, Delsym) is a cough suppressant. In our database it has 21 known interactions with common medicines and substances: 0 serious, 21 that need caution and 0 minor.
Use caution 21 interactions
Serotonin syndrome riskAmphetamine salts
Serotonin syndrome riskBuspirone
Serotonin syndrome riskCitalopram
Serotonin syndrome riskCyclobenzaprine
Serotonin syndrome riskDayQuil
Serotonin syndrome riskDuloxetine
Serotonin syndrome riskEscitalopram
Serotonin syndrome riskFluoxetine
Serotonin syndrome riskLisdexamfetamine
Serotonin syndrome riskLithium
Serotonin syndrome riskMirtazapine
Serotonin syndrome riskNyQuil
Serotonin syndrome riskOndansetron
Serotonin syndrome riskParoxetine
Serotonin syndrome riskSertraline
Serotonin syndrome riskSt. John's wort
Serotonin syndrome riskSumatriptan
Serotonin syndrome riskTramadol
Serotonin syndrome riskTrazodone
Serotonin syndrome riskVenlafaxine
Serotonin syndrome risk
No known interaction found
Our rules found no interaction between Dextromethorphan and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Empagliflozin, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisinopril, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Oseltamivir, Oxycodone, Pantoprazole, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, Sulfamethoxazole-trimethoprim, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Turmeric, Valacyclovir, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Dextromethorphan on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.