Levofloxacin interactions
Overview
Levofloxacin (Levaquin) is a fluoroquinolone antibiotic. In our database it has 21 known interactions with common medicines and substances: 0 serious, 20 that need caution and 1 minor.
Use caution 20 interactions
Heart rhythm (QT) riskAzithromycin
Heart rhythm (QT) riskBismuth subsalicylate
Minerals block the antibioticCalcium carbonate
Minerals block the antibioticCiprofloxacin
Heart rhythm (QT) riskCitalopram
Heart rhythm (QT) riskEscitalopram
Heart rhythm (QT) riskFluconazole
Heart rhythm (QT) riskFluoxetine
Heart rhythm (QT) riskHydroxychloroquine
Heart rhythm (QT) riskHydroxyzine
Heart rhythm (QT) riskIron supplements
Minerals block the antibioticMagnesium
Minerals block the antibioticMethylprednisolone
Higher risk of tendon ruptureOndansetron
Heart rhythm (QT) riskPrednisone
Higher risk of tendon ruptureQuetiapine
Heart rhythm (QT) riskTrazodone
Heart rhythm (QT) riskWarfarin
Antibiotics can change warfarin's effectZinc
Minerals block the antibiotic
Minor 1 interaction
No known interaction found
Our rules found no interaction between Levofloxacin and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Atorvastatin, Baclofen, Birth control pills, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Ibuprofen, Insulin, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Oseltamivir, Oxycodone, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Pregabalin, Promethazine, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Levofloxacin on DailyMed (effective 2026-07), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.