Skip to content

Levofloxacin interactions

Updated October 4, 2026How we check

Overview

Levofloxacin (Levaquin) is a fluoroquinolone antibiotic. In our database it has 21 known interactions with common medicines and substances: 0 serious, 20 that need caution and 1 minor.

Use caution 20 interactions

Minor 1 interaction

No known interaction found

Our rules found no interaction between Levofloxacin and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Atorvastatin, Baclofen, Birth control pills, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Ibuprofen, Insulin, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Oseltamivir, Oxycodone, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Pregabalin, Promethazine, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Zolpidem.

Add at least two medicines, supplements or alcohol.

Sources

Source: FDA label for Levofloxacin on DailyMed (effective 2026-07), plus the labels of each interacting medicine.

This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.