Oxycodone interactions
Overview
Oxycodone (OxyContin, Percocet) is an opioid pain medicine (Percocet also contains acetaminophen). In our database it has 45 known interactions with common medicines and substances: 33 serious, 10 that need caution and 2 minor.
Avoid / serious 33 interactions
Alcohol and opioids can stop your breathingAlprazolam
Dangerous breathing and sedation riskAmitriptyline
Too much sedation and slowed breathingBaclofen
Too much sedation and slowed breathingBuprenorphine-naloxone
Two opioids at onceCannabis
Too much sedation and slowed breathingClonazepam
Dangerous breathing and sedation riskClonidine
Too much sedation and slowed breathingCodeine
Two opioids at onceCyclobenzaprine
Too much sedation and slowed breathingDiazepam
Dangerous breathing and sedation riskDiphenhydramine
Too much sedation and slowed breathingDoxylamine
Too much sedation and slowed breathingGabapentin
Serious breathing problemsHydrocodone
Two opioids at onceHydroxyzine
Too much sedation and slowed breathingKratom
Too much sedation and slowed breathingLevetiracetam
Too much sedation and slowed breathingLorazepam
Dangerous breathing and sedation riskMeclizine
Too much sedation and slowed breathingMethocarbamol
Too much sedation and slowed breathingMirtazapine
Too much sedation and slowed breathingMorphine
Two opioids at onceNaltrexone
Naltrexone blocks opioids and can trigger withdrawalNyQuil
Too much sedation and slowed breathingPaxlovid
Paxlovid can raise this medicine to unsafe levelsPregabalin
Serious breathing problemsPromethazine
Too much sedation and slowed breathingQuetiapine
Too much sedation and slowed breathingTizanidine
Too much sedation and slowed breathingTramadol
Two opioids at onceTrazodone
Too much sedation and slowed breathingZolpidem
Too much sedation and slowed breathing
Use caution 10 interactions
Check whether your opioid also contains acetaminophenCitalopram
Serotonin syndrome and seizure riskDayQuil
Check whether your opioid also contains acetaminophenDuloxetine
Serotonin syndrome and seizure riskEscitalopram
Serotonin syndrome and seizure riskExcedrin
Check whether your opioid also contains acetaminophenFluoxetine
Serotonin syndrome and seizure riskParoxetine
Serotonin syndrome and seizure riskSertraline
Serotonin syndrome and seizure riskVenlafaxine
Serotonin syndrome and seizure risk
Minor 2 interactions
No known interaction found
Our rules found no interaction between Oxycodone and: Acyclovir, Albuterol, Allopurinol, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Aspirin, Atenolol, Atorvastatin, Azithromycin, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clopidogrel, Colchicine, Creatine, Dextromethorphan, Diclofenac, Digoxin, Doxycycline, Empagliflozin, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Furosemide, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Losartan, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Oxycodone on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.