Naltrexone interactions
Overview
Naltrexone (Vivitrol, ReVia) is a medicine for alcohol and opioid use disorder. In our database it has 7 known interactions with common medicines and substances: 7 serious, 0 that need caution and 0 minor.
Avoid / serious 7 interactions
Naltrexone blocks opioids and can trigger withdrawalCodeine
Naltrexone blocks opioids and can trigger withdrawalHydrocodone
Naltrexone blocks opioids and can trigger withdrawalKratom
Naltrexone blocks opioids and can trigger withdrawalMorphine
Naltrexone blocks opioids and can trigger withdrawalOxycodone
Naltrexone blocks opioids and can trigger withdrawalTramadol
Naltrexone blocks opioids and can trigger withdrawal
No known interaction found
Our rules found no interaction between Naltrexone and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Hydroxyzine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Trazodone, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Naltrexone on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.