Amitriptyline interactions
Overview
Amitriptyline (Elavil) is a tricyclic antidepressant also used for pain and sleep. In our database it has 55 known interactions with common medicines and substances: 7 serious, 46 that need caution and 2 minor.
Avoid / serious 7 interactions
Too much sedation and slowed breathingCodeine
Too much sedation and slowed breathingHydrocodone
Too much sedation and slowed breathingKratom
Too much sedation and slowed breathingMorphine
Too much sedation and slowed breathingOxycodone
Too much sedation and slowed breathingTramadol
Too much sedation and slowed breathing
Use caution 46 interactions
Combined drowsinessAlprazolam
Extra drowsiness and slowed reactionsAmphetamine salts
Serotonin syndrome riskAzithromycin
Heart rhythm (QT) riskBaclofen
Combined drowsinessBupropion
Higher seizure riskBuspirone
Serotonin syndrome riskCannabis
Combined drowsinessCiprofloxacin
Heart rhythm (QT) riskCitalopram
Serotonin syndrome riskClonazepam
Extra drowsiness and slowed reactionsClonidine
Combined drowsinessCyclobenzaprine
Combined drowsinessDayQuil
Serotonin syndrome riskDextromethorphan
Serotonin syndrome riskDiazepam
Extra drowsiness and slowed reactionsDiphenhydramine
Combined drowsinessDoxylamine
Combined drowsinessDuloxetine
Serotonin syndrome riskEscitalopram
Serotonin syndrome riskFluconazole
Heart rhythm (QT) riskFluoxetine
Serotonin syndrome riskGabapentin
Combined drowsinessHydroxychloroquine
Heart rhythm (QT) riskHydroxyzine
Combined drowsinessLevetiracetam
Combined drowsinessLevofloxacin
Heart rhythm (QT) riskLisdexamfetamine
Serotonin syndrome riskLithium
Serotonin syndrome riskLorazepam
Extra drowsiness and slowed reactionsMeclizine
Combined drowsinessMethocarbamol
Combined drowsinessMirtazapine
Combined drowsinessNyQuil
Combined drowsinessOndansetron
Serotonin syndrome riskParoxetine
Serotonin syndrome riskPregabalin
Combined drowsinessPromethazine
Combined drowsinessQuetiapine
Combined drowsinessSertraline
Serotonin syndrome riskSt. John's wort
Serotonin syndrome riskSumatriptan
Serotonin syndrome riskTizanidine
Combined drowsinessTrazodone
Combined drowsinessVenlafaxine
Serotonin syndrome riskZolpidem
Extra drowsiness and slowed reactions
Minor 2 interactions
No known interaction found
Our rules found no interaction between Amitriptyline and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Apixaban, Aripiprazole, Aspirin, Atenolol, Atorvastatin, Birth control pills, Bismuth subsalicylate, Caffeine, Calcium carbonate, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Clindamycin, Clopidogrel, Colchicine, Creatine, Diclofenac, Digoxin, Doxycycline, Empagliflozin, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Furosemide, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levothyroxine, Lisinopril, Loperamide, Loratadine, Losartan, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Oseltamivir, Pantoprazole, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, Sulfamethoxazole-trimethoprim, Tadalafil, Tamsulosin, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Amitriptyline on DailyMed (effective 2026-06), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.