Bismuth subsalicylate interactions
Overview
Bismuth subsalicylate (Pepto-Bismol) is a stomach and diarrhea medicine with a salicylate. In our database it has 21 known interactions with common medicines and substances: 4 serious, 17 that need caution and 0 minor.
Avoid / serious 4 interactions
Higher risk of serious bleedingMethotrexate
Can raise methotrexate to dangerous levelsRivaroxaban
Higher risk of serious bleedingWarfarin
Higher risk of serious bleeding
Use caution 17 interactions
Pepto-Bismol contains a salicylate (aspirin-like)Celecoxib
Pepto-Bismol contains a salicylate (aspirin-like)Ciprofloxacin
Minerals block the antibioticCitalopram
Higher bleeding riskDiclofenac
Pepto-Bismol contains a salicylate (aspirin-like)Doxycycline
Minerals block the antibioticDuloxetine
Higher bleeding riskEscitalopram
Higher bleeding riskExcedrin
Pepto-Bismol contains a salicylate (aspirin-like)Fluoxetine
Higher bleeding riskIbuprofen
Pepto-Bismol contains a salicylate (aspirin-like)Levofloxacin
Minerals block the antibioticMeloxicam
Pepto-Bismol contains a salicylate (aspirin-like)Naproxen
Pepto-Bismol contains a salicylate (aspirin-like)Paroxetine
Higher bleeding riskSertraline
Higher bleeding riskVenlafaxine
Higher bleeding risk
No known interaction found
Our rules found no interaction between Bismuth subsalicylate and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Aripiprazole, Ashwagandha, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Cephalexin, Cetirizine, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Digoxin, Diphenhydramine, Doxylamine, Empagliflozin, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Trazodone, Turmeric, Valacyclovir, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Bismuth subsalicylate on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.