Cannabis interactions
Overview
Cannabis (marijuana, THC, CBD) is cannabis products including THC and CBD. In our database it has 33 known interactions with common medicines and substances: 7 serious, 24 that need caution and 2 minor.
Avoid / serious 7 interactions
Too much sedation and slowed breathingCodeine
Too much sedation and slowed breathingHydrocodone
Too much sedation and slowed breathingKratom
Too much sedation and slowed breathingMorphine
Too much sedation and slowed breathingOxycodone
Too much sedation and slowed breathingTramadol
Too much sedation and slowed breathing
Use caution 24 interactions
Combined drowsinessAlprazolam
Extra drowsiness and slowed reactionsAmitriptyline
Combined drowsinessBaclofen
Combined drowsinessClonazepam
Extra drowsiness and slowed reactionsClonidine
Combined drowsinessCyclobenzaprine
Combined drowsinessDiazepam
Extra drowsiness and slowed reactionsDiphenhydramine
Combined drowsinessDoxylamine
Combined drowsinessGabapentin
Combined drowsinessHydroxyzine
Combined drowsinessLevetiracetam
Combined drowsinessLorazepam
Extra drowsiness and slowed reactionsMeclizine
Combined drowsinessMethocarbamol
Combined drowsinessMirtazapine
Combined drowsinessNyQuil
Combined drowsinessPregabalin
Combined drowsinessPromethazine
Combined drowsinessQuetiapine
Combined drowsinessTizanidine
Combined drowsinessTrazodone
Combined drowsinessZolpidem
Extra drowsiness and slowed reactions
Minor 2 interactions
No known interaction found
Our rules found no interaction between Cannabis and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Aspirin, Atenolol, Atorvastatin, Azithromycin, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clopidogrel, Colchicine, Creatine, DayQuil, Dextromethorphan, Diclofenac, Digoxin, Doxycycline, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Losartan, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
There is no single FDA label for this item, so interactions listed here come from the FDA labels of the medicines it interacts with, and from NIH guidance where noted.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.