Clonidine interactions
Overview
Clonidine (Catapres) is a blood pressure medicine also used for ADHD and withdrawal. In our database it has 49 known interactions with common medicines and substances: 7 serious, 31 that need caution and 11 minor.
Avoid / serious 7 interactions
Too much sedation and slowed breathingCodeine
Too much sedation and slowed breathingHydrocodone
Too much sedation and slowed breathingKratom
Too much sedation and slowed breathingMorphine
Too much sedation and slowed breathingOxycodone
Too much sedation and slowed breathingTramadol
Too much sedation and slowed breathing
Use caution 31 interactions
Combined drowsinessAlprazolam
Extra drowsiness and slowed reactionsAmitriptyline
Combined drowsinessAtenolol
Slow heart rate and heart block riskBaclofen
Combined drowsinessCannabis
Combined drowsinessCarvedilol
Slow heart rate and heart block riskClonazepam
Extra drowsiness and slowed reactionsCyclobenzaprine
Combined drowsinessDayQuil
Can raise blood pressure and heart rateDiazepam
Extra drowsiness and slowed reactionsDiphenhydramine
Combined drowsinessDoxylamine
Combined drowsinessGabapentin
Combined drowsinessHydroxyzine
Combined drowsinessLevetiracetam
Combined drowsinessLorazepam
Extra drowsiness and slowed reactionsMeclizine
Combined drowsinessMethocarbamol
Combined drowsinessMetoprolol
Slow heart rate and heart block riskMirtazapine
Combined drowsinessNyQuil
Combined drowsinessPhenylephrine
Can raise blood pressure and heart ratePregabalin
Combined drowsinessPromethazine
Combined drowsinessPropranolol
Slow heart rate and heart block riskPseudoephedrine
Can raise blood pressure and heart rateQuetiapine
Combined drowsinessTizanidine
Combined drowsinessTrazodone
Combined drowsinessZolpidem
Extra drowsiness and slowed reactions
Minor 11 interactions
Additive blood pressure loweringAshwagandha
A bit more drowsinessFurosemide
Additive blood pressure loweringHydrochlorothiazide
Additive blood pressure loweringLisinopril
Additive blood pressure loweringLosartan
Additive blood pressure loweringMelatonin
A bit more drowsinessSildenafil
Small extra drop in blood pressureSpironolactone
Additive blood pressure loweringTadalafil
Small extra drop in blood pressureTamsulosin
Additive blood pressure lowering
No known interaction found
Our rules found no interaction between Clonidine and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Aspirin, Atorvastatin, Azithromycin, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clopidogrel, Colchicine, Creatine, Dextromethorphan, Diclofenac, Digoxin, Doxycycline, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Glipizide, Grapefruit juice, Guaifenesin, Hydroxychloroquine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lithium, Loperamide, Loratadine, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metronidazole, Montelukast, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Simvastatin, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Clonidine on DailyMed (effective 2025-03), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.