DayQuil interactions
Overview
DayQuil (Vicks DayQuil) is a daytime cold medicine with acetaminophen, dextromethorphan and phenylephrine. In our database it has 45 known interactions with common medicines and substances: 3 serious, 40 that need caution and 2 minor.
Avoid / serious 3 interactions
Double acetaminophen can damage your liverExcedrin
Double acetaminophen can damage your liverNyQuil
Double acetaminophen can damage your liver
Use caution 40 interactions
Liver damage risk with heavy drinkingAmitriptyline
Serotonin syndrome riskAmlodipine
Can raise blood pressure and heart rateAmphetamine salts
Serotonin syndrome riskAtenolol
Can raise blood pressure and heart rateBuspirone
Serotonin syndrome riskCarvedilol
Can raise blood pressure and heart rateCitalopram
Serotonin syndrome riskClonidine
Can raise blood pressure and heart rateCyclobenzaprine
Serotonin syndrome riskDextromethorphan
Serotonin syndrome riskDuloxetine
Serotonin syndrome riskEscitalopram
Serotonin syndrome riskFluoxetine
Serotonin syndrome riskFurosemide
Can raise blood pressure and heart rateHydrochlorothiazide
Can raise blood pressure and heart rateHydrocodone
Check whether your opioid also contains acetaminophenLisdexamfetamine
Serotonin syndrome riskLisinopril
Can raise blood pressure and heart rateLithium
Serotonin syndrome riskLosartan
Can raise blood pressure and heart rateMethylphenidate
Can raise blood pressure and heart rateMetoprolol
Can raise blood pressure and heart rateMirtazapine
Serotonin syndrome riskOndansetron
Serotonin syndrome riskOxycodone
Check whether your opioid also contains acetaminophenParoxetine
Serotonin syndrome riskPhentermine
Can raise blood pressure and heart ratePhenylephrine
Can raise blood pressure and heart ratePropranolol
Can raise blood pressure and heart ratePseudoephedrine
Can raise blood pressure and heart rateSertraline
Serotonin syndrome riskSpironolactone
Can raise blood pressure and heart rateSt. John's wort
Serotonin syndrome riskSumatriptan
Serotonin syndrome riskTamsulosin
Can raise blood pressure and heart rateTizanidine
Can raise blood pressure and heart rateTramadol
Serotonin syndrome riskTrazodone
Serotonin syndrome riskVenlafaxine
Serotonin syndrome risk
Minor 2 interactions
No known interaction found
Our rules found no interaction between DayQuil and: Acyclovir, Albuterol, Allopurinol, Alprazolam, Amoxicillin, Amoxicillin-clavulanate, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Calcium carbonate, Cannabis, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clopidogrel, Codeine, Colchicine, Creatine, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Empagliflozin, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydroxychloroquine, Hydroxyzine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Loperamide, Loratadine, Lorazepam, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylprednisolone, Metronidazole, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Oseltamivir, Pantoprazole, Paxlovid, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Sulfamethoxazole-trimethoprim, Tadalafil, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for DayQuil on DailyMed (effective 2026-06), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.