Diazepam interactions
Overview
Diazepam (Valium) is a benzodiazepine for anxiety and muscle spasm. In our database it has 34 known interactions with common medicines and substances: 9 serious, 23 that need caution and 2 minor.
Avoid / serious 9 interactions
Alcohol greatly increases sedationBuprenorphine-naloxone
Dangerous breathing and sedation riskCodeine
Dangerous breathing and sedation riskHydrocodone
Dangerous breathing and sedation riskKratom
Dangerous breathing and sedation riskMorphine
Dangerous breathing and sedation riskOxycodone
Dangerous breathing and sedation riskPaxlovid
Paxlovid can raise this medicine to unsafe levelsTramadol
Dangerous breathing and sedation risk
Use caution 23 interactions
Extra drowsiness and slowed reactionsAmitriptyline
Extra drowsiness and slowed reactionsBaclofen
Extra drowsiness and slowed reactionsCannabis
Extra drowsiness and slowed reactionsClonazepam
Extra drowsiness and slowed reactionsClonidine
Extra drowsiness and slowed reactionsCyclobenzaprine
Extra drowsiness and slowed reactionsDiphenhydramine
Extra drowsiness and slowed reactionsDoxylamine
Extra drowsiness and slowed reactionsGabapentin
Extra drowsiness and slowed reactionsHydroxyzine
Extra drowsiness and slowed reactionsLevetiracetam
Extra drowsiness and slowed reactionsLorazepam
Extra drowsiness and slowed reactionsMeclizine
Extra drowsiness and slowed reactionsMethocarbamol
Extra drowsiness and slowed reactionsMirtazapine
Extra drowsiness and slowed reactionsNyQuil
Extra drowsiness and slowed reactionsPregabalin
Extra drowsiness and slowed reactionsPromethazine
Extra drowsiness and slowed reactionsQuetiapine
Extra drowsiness and slowed reactionsTizanidine
Extra drowsiness and slowed reactionsTrazodone
Extra drowsiness and slowed reactionsZolpidem
Extra drowsiness and slowed reactions
Minor 2 interactions
No known interaction found
Our rules found no interaction between Diazepam and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Aspirin, Atenolol, Atorvastatin, Azithromycin, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clopidogrel, Colchicine, Creatine, DayQuil, Dextromethorphan, Diclofenac, Digoxin, Doxycycline, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Losartan, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paroxetine, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Diazepam on DailyMed (effective 2026-08), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.