Empagliflozin interactions
Overview
Empagliflozin (Jardiance) is an SGLT2 diabetes and heart medicine. In our database it has 15 known interactions with common medicines and substances: 0 serious, 15 that need caution and 0 minor.
Use caution 15 interactions
Low blood sugar and other risksAspirin
Can strain the kidneys and weaken blood pressure controlCelecoxib
Can strain the kidneys and weaken blood pressure controlDiclofenac
Can strain the kidneys and weaken blood pressure controlExcedrin
Can strain the kidneys and weaken blood pressure controlFurosemide
Dehydration and low blood pressureGlipizide
Higher risk of low blood sugarHydrochlorothiazide
Dehydration and low blood pressureIbuprofen
Can strain the kidneys and weaken blood pressure controlInsulin
Higher risk of low blood sugarMeloxicam
Can strain the kidneys and weaken blood pressure controlMethylprednisolone
Steroids raise blood sugarNaproxen
Can strain the kidneys and weaken blood pressure controlPrednisone
Steroids raise blood sugarSpironolactone
Dehydration and low blood pressure
No known interaction found
Our rules found no interaction between Empagliflozin and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Escitalopram, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Gabapentin, Grapefruit juice, Guaifenesin, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Trazodone, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Empagliflozin on DailyMed (effective 2026-08), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.