Excedrin interactions
Overview
Excedrin is a headache tablet with acetaminophen, aspirin and caffeine. In our database it has 42 known interactions with common medicines and substances: 8 serious, 28 that need caution and 6 minor.
Avoid / serious 8 interactions
Double acetaminophen can damage your liverApixaban
Higher risk of serious bleedingDayQuil
Double acetaminophen can damage your liverLithium
Can raise lithium to toxic levelsMethotrexate
Can raise methotrexate to dangerous levelsNyQuil
Double acetaminophen can damage your liverRivaroxaban
Higher risk of serious bleedingWarfarin
Higher risk of serious bleeding
Use caution 28 interactions
Stomach bleeding riskAspirin
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionBismuth subsalicylate
Pepto-Bismol contains a salicylate (aspirin-like)Celecoxib
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionCitalopram
Higher bleeding riskClopidogrel
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionDiclofenac
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionDuloxetine
Higher bleeding riskEmpagliflozin
Can strain the kidneys and weaken blood pressure controlEscitalopram
Higher bleeding riskFish oil
May add to bleeding riskFluoxetine
Higher bleeding riskFurosemide
Can strain the kidneys and weaken blood pressure controlHydrochlorothiazide
Can strain the kidneys and weaken blood pressure controlHydrocodone
Check whether your opioid also contains acetaminophenIbuprofen
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionLisinopril
Can strain the kidneys and weaken blood pressure controlLosartan
Can strain the kidneys and weaken blood pressure controlMeloxicam
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionMethylprednisolone
Higher risk of stomach ulcers and bleedingNaproxen
More stomach bleeding risk, and ibuprofen can blunt aspirin's heart protectionOxycodone
Check whether your opioid also contains acetaminophenParoxetine
Higher bleeding riskPrednisone
Higher risk of stomach ulcers and bleedingSertraline
Higher bleeding riskSpironolactone
Can strain the kidneys and weaken blood pressure controlTurmeric
May add to bleeding riskVenlafaxine
Higher bleeding risk
Minor 6 interactions
Extra jitteriness and fast heartbeatLisdexamfetamine
Extra jitteriness and fast heartbeatMethylphenidate
Extra jitteriness and fast heartbeatPhentermine
Extra jitteriness and fast heartbeatPhenylephrine
Extra jitteriness and fast heartbeatPseudoephedrine
Extra jitteriness and fast heartbeat
No known interaction found
Our rules found no interaction between Excedrin and: Acyclovir, Albuterol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Aripiprazole, Ashwagandha, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clonidine, Codeine, Colchicine, Creatine, Cyclobenzaprine, Dextromethorphan, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fluconazole, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydroxychloroquine, Hydroxyzine, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Loperamide, Loratadine, Lorazepam, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paxlovid, Potassium supplements, Pravastatin, Pregabalin, Probiotics, Promethazine, Propranolol, Quetiapine, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Trazodone, Valacyclovir, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Excedrin on DailyMed (effective 2025-12), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.