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Fluconazole interactions

Updated October 4, 2026How we check

Overview

Fluconazole (Diflucan) is an azole antifungal. In our database it has 17 known interactions with common medicines and substances: 1 serious, 16 that need caution and 0 minor.

Avoid / serious 1 interaction

Use caution 16 interactions

No known interaction found

Our rules found no interaction between Fluconazole and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Furosemide, Gabapentin, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Ibuprofen, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Oseltamivir, Oxycodone, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Zinc, Zolpidem.

Add at least two medicines, supplements or alcohol.

Sources

Source: FDA label for Fluconazole on DailyMed (effective 2026-09), plus the labels of each interacting medicine.

This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.