Fluconazole interactions
Overview
Fluconazole (Diflucan) is an azole antifungal. In our database it has 17 known interactions with common medicines and substances: 1 serious, 16 that need caution and 0 minor.
Avoid / serious 1 interaction
Use caution 16 interactions
Heart rhythm (QT) riskAtorvastatin
Raises levels of the other medicineAzithromycin
Heart rhythm (QT) riskCiprofloxacin
Heart rhythm (QT) riskCitalopram
Heart rhythm (QT) riskEscitalopram
Heart rhythm (QT) riskFluoxetine
Heart rhythm (QT) riskGlipizide
Raises levels of the other medicineHydroxychloroquine
Heart rhythm (QT) riskHydroxyzine
Heart rhythm (QT) riskInsulin
Raises levels of the other medicineLevofloxacin
Heart rhythm (QT) riskOndansetron
Heart rhythm (QT) riskQuetiapine
Heart rhythm (QT) riskSimvastatin
Raises levels of the other medicineTrazodone
Heart rhythm (QT) risk
No known interaction found
Our rules found no interaction between Fluconazole and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Furosemide, Gabapentin, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Ibuprofen, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Oseltamivir, Oxycodone, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Fluconazole on DailyMed (effective 2026-09), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.