Furosemide interactions
Overview
Furosemide (Lasix) is a loop diuretic (water pill). In our database it has 26 known interactions with common medicines and substances: 1 serious, 11 that need caution and 14 minor.
Avoid / serious 1 interaction
Use caution 11 interactions
Can strain the kidneys and weaken blood pressure controlCelecoxib
Can strain the kidneys and weaken blood pressure controlDayQuil
Can raise blood pressure and heart rateDiclofenac
Can strain the kidneys and weaken blood pressure controlEmpagliflozin
Dehydration and low blood pressureExcedrin
Can strain the kidneys and weaken blood pressure controlIbuprofen
Can strain the kidneys and weaken blood pressure controlMeloxicam
Can strain the kidneys and weaken blood pressure controlNaproxen
Can strain the kidneys and weaken blood pressure controlPhenylephrine
Can raise blood pressure and heart ratePseudoephedrine
Can raise blood pressure and heart rate
Minor 14 interactions
Additive blood pressure loweringAtenolol
Additive blood pressure loweringCarvedilol
Additive blood pressure loweringClonidine
Additive blood pressure loweringHydrochlorothiazide
Additive blood pressure loweringLisinopril
Additive blood pressure loweringLosartan
Additive blood pressure loweringMetoprolol
Additive blood pressure loweringPropranolol
Additive blood pressure loweringSildenafil
Small extra drop in blood pressureSpironolactone
Additive blood pressure loweringTadalafil
Small extra drop in blood pressureTamsulosin
Additive blood pressure loweringTizanidine
Additive blood pressure lowering
No known interaction found
Our rules found no interaction between Furosemide and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amitriptyline, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clonazepam, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, Dextromethorphan, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Escitalopram, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Loperamide, Loratadine, Lorazepam, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Simvastatin, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tirzepatide, Topiramate, Tramadol, Trazodone, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Furosemide on DailyMed (effective 2026-06), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.