Kratom interactions
Overview
Kratom is an unregulated plant product with opioid-like effects (not FDA approved). In our database it has 34 known interactions with common medicines and substances: 32 serious, 0 that need caution and 2 minor.
Avoid / serious 32 interactions
Alcohol and opioids can stop your breathingAlprazolam
Dangerous breathing and sedation riskAmitriptyline
Too much sedation and slowed breathingBaclofen
Too much sedation and slowed breathingBuprenorphine-naloxone
Too much sedation and slowed breathingCannabis
Too much sedation and slowed breathingClonazepam
Dangerous breathing and sedation riskClonidine
Too much sedation and slowed breathingCodeine
Too much sedation and slowed breathingCyclobenzaprine
Too much sedation and slowed breathingDiazepam
Dangerous breathing and sedation riskDiphenhydramine
Too much sedation and slowed breathingDoxylamine
Too much sedation and slowed breathingGabapentin
Serious breathing problemsHydrocodone
Too much sedation and slowed breathingHydroxyzine
Too much sedation and slowed breathingLevetiracetam
Too much sedation and slowed breathingLorazepam
Dangerous breathing and sedation riskMeclizine
Too much sedation and slowed breathingMethocarbamol
Too much sedation and slowed breathingMirtazapine
Too much sedation and slowed breathingMorphine
Too much sedation and slowed breathingNaltrexone
Naltrexone blocks opioids and can trigger withdrawalNyQuil
Too much sedation and slowed breathingOxycodone
Too much sedation and slowed breathingPregabalin
Serious breathing problemsPromethazine
Too much sedation and slowed breathingQuetiapine
Too much sedation and slowed breathingTizanidine
Too much sedation and slowed breathingTramadol
Too much sedation and slowed breathingTrazodone
Too much sedation and slowed breathingZolpidem
Too much sedation and slowed breathing
Minor 2 interactions
No known interaction found
Our rules found no interaction between Kratom and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Aspirin, Atenolol, Atorvastatin, Azithromycin, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clopidogrel, Colchicine, Creatine, DayQuil, Dextromethorphan, Diclofenac, Digoxin, Doxycycline, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Losartan, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
There is no single FDA label for this item, so interactions listed here come from the FDA labels of the medicines it interacts with, and from NIH guidance where noted.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.