Lithium interactions
Overview
Lithium (Lithobid) is a mood stabilizer for bipolar disorder. In our database it has 33 known interactions with common medicines and substances: 12 serious, 21 that need caution and 0 minor.
Avoid / serious 12 interactions
Can raise lithium to toxic levelsCelecoxib
Can raise lithium to toxic levelsDiclofenac
Can raise lithium to toxic levelsExcedrin
Can raise lithium to toxic levelsFurosemide
Can raise lithium to toxic levelsHydrochlorothiazide
Can raise lithium to toxic levelsIbuprofen
Can raise lithium to toxic levelsLisinopril
Can raise lithium to toxic levelsLosartan
Can raise lithium to toxic levelsMeloxicam
Can raise lithium to toxic levelsNaproxen
Can raise lithium to toxic levelsSpironolactone
Can raise lithium to toxic levels
Use caution 21 interactions
Serotonin syndrome riskAmphetamine salts
Serotonin syndrome riskBuspirone
Serotonin syndrome riskCitalopram
Serotonin syndrome riskCyclobenzaprine
Serotonin syndrome riskDayQuil
Serotonin syndrome riskDextromethorphan
Serotonin syndrome riskDuloxetine
Serotonin syndrome riskEscitalopram
Serotonin syndrome riskFluoxetine
Serotonin syndrome riskLisdexamfetamine
Serotonin syndrome riskMirtazapine
Serotonin syndrome riskNyQuil
Serotonin syndrome riskOndansetron
Serotonin syndrome riskParoxetine
Serotonin syndrome riskSertraline
Serotonin syndrome riskSt. John's wort
Serotonin syndrome riskSumatriptan
Serotonin syndrome riskTramadol
Serotonin syndrome riskTrazodone
Serotonin syndrome riskVenlafaxine
Serotonin syndrome risk
No known interaction found
Our rules found no interaction between Lithium and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Apixaban, Aripiprazole, Ashwagandha, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Empagliflozin, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Loperamide, Loratadine, Lorazepam, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, Omeprazole, Oseltamivir, Oxycodone, Pantoprazole, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Sulfamethoxazole-trimethoprim, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Turmeric, Valacyclovir, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Lithium on DailyMed (effective 2026-08), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.