Skip to content
Medication Interaction CheckerSourced from FDA labels Check interactions
Check interactions Drugs A to Z →Interaction guides → How we check →About →
Popular medicines
IbuprofenAcetaminophenAlcoholSertralineGabapentinMetforminSemaglutideAlprazolam

Methotrexate interactions

Updated October 4, 2026How we check

Overview

Methotrexate (Trexall, Otrexup) is a medicine for rheumatoid arthritis, psoriasis and some cancers. In our database it has 9 known interactions with common medicines and substances: 9 serious, 0 that need caution and 0 minor.

Avoid / serious 9 interactions

Aspirin
Can raise methotrexate to dangerous levelsBismuth subsalicylate
Can raise methotrexate to dangerous levelsCelecoxib
Can raise methotrexate to dangerous levelsDiclofenac
Can raise methotrexate to dangerous levelsExcedrin
Can raise methotrexate to dangerous levelsIbuprofen
Can raise methotrexate to dangerous levelsMeloxicam
Can raise methotrexate to dangerous levelsNaproxen
Can raise methotrexate to dangerous levelsSulfamethoxazole-trimethoprim
Can raise methotrexate to dangerous levels

No known interaction found

Our rules found no interaction between Methotrexate and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Metformin, Methocarbamol, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Trazodone, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc, Zolpidem.

Add at least two medicines, supplements or alcohol.

Try: Advil + Tylenol · Zoloft + Advil · Flagyl + alcohol

Sources

Source: FDA label for Methotrexate on DailyMed (effective 2026-08), plus the labels of each interacting medicine.

This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.