Omeprazole interactions
Overview
Omeprazole (Prilosec) is a proton pump inhibitor (PPI) that lowers stomach acid. In our database it has 5 known interactions with common medicines and substances: 0 serious, 2 that need caution and 3 minor.
Use caution 2 interactions
Minor 3 interactions
In-depth guides
No known interaction found
Our rules found no interaction between Omeprazole and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amitriptyline, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clonazepam, Clonidine, Codeine, Colchicine, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Escitalopram, Estradiol, Excedrin, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Ondansetron, Oseltamivir, Oxycodone, Paroxetine, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, Spironolactone, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Tramadol, Trazodone, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Omeprazole on DailyMed (effective 2026-08), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.