Ondansetron interactions
Overview
Ondansetron (Zofran) is a prescription anti-nausea medicine. In our database it has 28 known interactions with common medicines and substances: 0 serious, 28 that need caution and 0 minor.
Use caution 28 interactions
Serotonin syndrome riskAmphetamine salts
Serotonin syndrome riskAzithromycin
Heart rhythm (QT) riskBuspirone
Serotonin syndrome riskCiprofloxacin
Heart rhythm (QT) riskCitalopram
Serotonin syndrome riskCyclobenzaprine
Serotonin syndrome riskDayQuil
Serotonin syndrome riskDextromethorphan
Serotonin syndrome riskDuloxetine
Serotonin syndrome riskEscitalopram
Serotonin syndrome riskFluconazole
Heart rhythm (QT) riskFluoxetine
Serotonin syndrome riskHydroxychloroquine
Heart rhythm (QT) riskHydroxyzine
Heart rhythm (QT) riskLevofloxacin
Heart rhythm (QT) riskLisdexamfetamine
Serotonin syndrome riskLithium
Serotonin syndrome riskMirtazapine
Serotonin syndrome riskNyQuil
Serotonin syndrome riskParoxetine
Serotonin syndrome riskQuetiapine
Heart rhythm (QT) riskSertraline
Serotonin syndrome riskSt. John's wort
Serotonin syndrome riskSumatriptan
Serotonin syndrome riskTramadol
Serotonin syndrome riskTrazodone
Serotonin syndrome riskVenlafaxine
Serotonin syndrome risk
No known interaction found
Our rules found no interaction between Ondansetron and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atenolol, Atorvastatin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Clindamycin, Clonazepam, Clonidine, Clopidogrel, Codeine, Colchicine, Creatine, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Empagliflozin, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydrocodone, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levothyroxine, Lisinopril, Loperamide, Loratadine, Lorazepam, Losartan, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Oseltamivir, Oxycodone, Pantoprazole, Paxlovid, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, Sulfamethoxazole-trimethoprim, Tadalafil, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Turmeric, Valacyclovir, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Ondansetron on DailyMed (effective 2026-08), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.