Paxlovid interactions
Overview
Paxlovid is a COVID-19 antiviral (nirmatrelvir with ritonavir). In our database it has 22 known interactions with common medicines and substances: 22 serious, 0 that need caution and 0 minor.
Avoid / serious 22 interactions
Paxlovid can raise this medicine to unsafe levelsAmlodipine
Paxlovid can raise this medicine to unsafe levelsApixaban
Paxlovid can raise this medicine to unsafe levelsAripiprazole
Paxlovid can raise this medicine to unsafe levelsAtorvastatin
Paxlovid can raise this medicine to unsafe levelsBuprenorphine-naloxone
Paxlovid can raise this medicine to unsafe levelsClonazepam
Paxlovid can raise this medicine to unsafe levelsCodeine
Paxlovid can raise this medicine to unsafe levelsColchicine
Paxlovid can raise this medicine to unsafe levelsDiazepam
Paxlovid can raise this medicine to unsafe levelsHydrocodone
Paxlovid can raise this medicine to unsafe levelsLorazepam
Paxlovid can raise this medicine to unsafe levelsMorphine
Paxlovid can raise this medicine to unsafe levelsOxycodone
Paxlovid can raise this medicine to unsafe levelsQuetiapine
Paxlovid can raise this medicine to unsafe levelsRivaroxaban
Paxlovid can raise this medicine to unsafe levelsSildenafil
Paxlovid can raise this medicine to unsafe levelsSimvastatin
Paxlovid can raise this medicine to unsafe levelsSt. John's wort
Can make your medicine stop workingTadalafil
Paxlovid can raise this medicine to unsafe levelsTramadol
Paxlovid can raise this medicine to unsafe levelsZolpidem
Paxlovid can raise this medicine to unsafe levels
No known interaction found
Our rules found no interaction between Paxlovid and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Amitriptyline, Amoxicillin, Amoxicillin-clavulanate, Amphetamine salts, Ashwagandha, Aspirin, Atenolol, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Bupropion, Buspirone, Caffeine, Calcium carbonate, Cannabis, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clonidine, Clopidogrel, Creatine, Cyclobenzaprine, DayQuil, Dextromethorphan, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Furosemide, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Hydroxyzine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lisdexamfetamine, Lisinopril, Lithium, Loperamide, Loratadine, Losartan, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Mirtazapine, Montelukast, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Pantoprazole, Paroxetine, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Propranolol, Pseudoephedrine, Rosuvastatin, Semaglutide, Sertraline, Spironolactone, Sulfamethoxazole-trimethoprim, Sumatriptan, Tamsulosin, Tirzepatide, Tizanidine, Topiramate, Trazodone, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Paxlovid on DailyMed (effective 2026-02), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.