Phenylephrine interactions
Overview
Phenylephrine (Sudafed PE) is a nasal decongestant. In our database it has 21 known interactions with common medicines and substances: 0 serious, 19 that need caution and 2 minor.
Use caution 19 interactions
Can raise blood pressure and heart rateAmphetamine salts
Can raise blood pressure and heart rateAtenolol
Can raise blood pressure and heart rateCarvedilol
Can raise blood pressure and heart rateClonidine
Can raise blood pressure and heart rateDayQuil
Can raise blood pressure and heart rateFurosemide
Can raise blood pressure and heart rateHydrochlorothiazide
Can raise blood pressure and heart rateLisdexamfetamine
Can raise blood pressure and heart rateLisinopril
Can raise blood pressure and heart rateLosartan
Can raise blood pressure and heart rateMethylphenidate
Can raise blood pressure and heart rateMetoprolol
Can raise blood pressure and heart ratePhentermine
Can raise blood pressure and heart ratePropranolol
Can raise blood pressure and heart ratePseudoephedrine
Can raise blood pressure and heart rateSpironolactone
Can raise blood pressure and heart rateTamsulosin
Can raise blood pressure and heart rateTizanidine
Can raise blood pressure and heart rate
Minor 2 interactions
No known interaction found
Our rules found no interaction between Phenylephrine and: Acetaminophen, Acyclovir, Albuterol, Alcohol, Allopurinol, Alprazolam, Amitriptyline, Amoxicillin, Amoxicillin-clavulanate, Apixaban, Aripiprazole, Ashwagandha, Aspirin, Atorvastatin, Azithromycin, Baclofen, Birth control pills, Bismuth subsalicylate, Buprenorphine-naloxone, Bupropion, Buspirone, Calcium carbonate, Cannabis, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Citalopram, Clindamycin, Clonazepam, Clopidogrel, Codeine, Colchicine, Creatine, Cyclobenzaprine, Dextromethorphan, Diazepam, Diclofenac, Digoxin, Diphenhydramine, Doxycycline, Doxylamine, Duloxetine, Empagliflozin, Escitalopram, Esomeprazole, Estradiol, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Fluoxetine, Gabapentin, Glipizide, Grapefruit juice, Guaifenesin, Hydrocodone, Hydroxychloroquine, Hydroxyzine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Kratom, Lamotrigine, Levetiracetam, Levofloxacin, Levothyroxine, Lithium, Loperamide, Loratadine, Lorazepam, Magnesium, Meclizine, Melatonin, Meloxicam, Metformin, Methocarbamol, Methotrexate, Methylprednisolone, Metronidazole, Mirtazapine, Montelukast, Morphine, Naltrexone, Naproxen, Nicotine, Nitrofurantoin, NyQuil, Omeprazole, Ondansetron, Oseltamivir, Oxycodone, Pantoprazole, Paroxetine, Paxlovid, Potassium supplements, Pravastatin, Prednisone, Pregabalin, Probiotics, Promethazine, Quetiapine, Rivaroxaban, Rosuvastatin, Semaglutide, Sertraline, Sildenafil, Simvastatin, St. John's wort, Sulfamethoxazole-trimethoprim, Sumatriptan, Tadalafil, Tirzepatide, Topiramate, Tramadol, Trazodone, Turmeric, Valacyclovir, Venlafaxine, Vitamin D, Warfarin, Zinc, Zolpidem.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Phenylephrine on DailyMed (effective 2026-07), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.