Tramadol interactions
Overview
Tramadol (Ultram) is an opioid pain medicine. In our database it has 52 known interactions with common medicines and substances: 33 serious, 17 that need caution and 2 minor.
Avoid / serious 33 interactions
Alcohol and opioids can stop your breathingAlprazolam
Dangerous breathing and sedation riskAmitriptyline
Too much sedation and slowed breathingBaclofen
Too much sedation and slowed breathingBuprenorphine-naloxone
Two opioids at onceCannabis
Too much sedation and slowed breathingClonazepam
Dangerous breathing and sedation riskClonidine
Too much sedation and slowed breathingCodeine
Two opioids at onceCyclobenzaprine
Too much sedation and slowed breathingDiazepam
Dangerous breathing and sedation riskDiphenhydramine
Too much sedation and slowed breathingDoxylamine
Too much sedation and slowed breathingGabapentin
Serious breathing problemsHydrocodone
Two opioids at onceHydroxyzine
Too much sedation and slowed breathingKratom
Too much sedation and slowed breathingLevetiracetam
Too much sedation and slowed breathingLorazepam
Dangerous breathing and sedation riskMeclizine
Too much sedation and slowed breathingMethocarbamol
Too much sedation and slowed breathingMirtazapine
Too much sedation and slowed breathingMorphine
Two opioids at onceNaltrexone
Naltrexone blocks opioids and can trigger withdrawalNyQuil
Too much sedation and slowed breathingOxycodone
Two opioids at oncePaxlovid
Paxlovid can raise this medicine to unsafe levelsPregabalin
Serious breathing problemsPromethazine
Too much sedation and slowed breathingQuetiapine
Too much sedation and slowed breathingTizanidine
Too much sedation and slowed breathingTrazodone
Too much sedation and slowed breathingZolpidem
Too much sedation and slowed breathing
Use caution 17 interactions
Serotonin syndrome riskBupropion
Higher seizure riskBuspirone
Serotonin syndrome riskCitalopram
Serotonin syndrome and seizure riskDayQuil
Serotonin syndrome riskDextromethorphan
Serotonin syndrome riskDuloxetine
Serotonin syndrome and seizure riskEscitalopram
Serotonin syndrome and seizure riskFluoxetine
Serotonin syndrome and seizure riskLisdexamfetamine
Serotonin syndrome riskLithium
Serotonin syndrome riskOndansetron
Serotonin syndrome riskParoxetine
Serotonin syndrome and seizure riskSertraline
Serotonin syndrome and seizure riskSt. John's wort
Serotonin syndrome riskSumatriptan
Serotonin syndrome riskVenlafaxine
Serotonin syndrome and seizure risk
Minor 2 interactions
No known interaction found
Our rules found no interaction between Tramadol and: Acetaminophen, Acyclovir, Albuterol, Allopurinol, Amlodipine, Amoxicillin, Amoxicillin-clavulanate, Apixaban, Aripiprazole, Aspirin, Atenolol, Atorvastatin, Azithromycin, Birth control pills, Bismuth subsalicylate, Caffeine, Calcium carbonate, Carvedilol, Celecoxib, Cephalexin, Cetirizine, Ciprofloxacin, Clindamycin, Clopidogrel, Colchicine, Creatine, Diclofenac, Digoxin, Doxycycline, Empagliflozin, Esomeprazole, Estradiol, Excedrin, Famotidine, Fexofenadine, Finasteride, Fish oil, Fluconazole, Furosemide, Glipizide, Grapefruit juice, Guaifenesin, Hydrochlorothiazide, Hydroxychloroquine, Ibuprofen, Insulin, Iron supplements, Isotretinoin, Lamotrigine, Levofloxacin, Levothyroxine, Lisinopril, Loperamide, Loratadine, Losartan, Magnesium, Meloxicam, Metformin, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Metronidazole, Montelukast, Naproxen, Nicotine, Nitrofurantoin, Omeprazole, Oseltamivir, Pantoprazole, Phentermine, Phenylephrine, Potassium supplements, Pravastatin, Prednisone, Probiotics, Propranolol, Pseudoephedrine, Rivaroxaban, Rosuvastatin, Semaglutide, Sildenafil, Simvastatin, Spironolactone, Sulfamethoxazole-trimethoprim, Tadalafil, Tamsulosin, Tirzepatide, Topiramate, Turmeric, Valacyclovir, Vitamin D, Warfarin, Zinc.
Add at least two medicines, supplements or alcohol.
Sources
Source: FDA label for Tramadol on DailyMed (effective 2026-07), plus the labels of each interacting medicine.
This list covers the 147 medicines and substances in our database. It is not a complete list of every possible interaction. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you take.