Know what’s safe to take together.
Check prescriptions, over-the-counter medicines, supplements and alcohol in seconds. Get a plain-English answer, what to do about it, and the exact FDA label text behind every warning.
Add at least two medicines, supplements or alcohol.
Start with the medicines you take
Every medicine has its own page listing what it interacts with, sorted from most to least serious.
Not just a warning. The reason, the fix, and the source.
Here is a real result from the checker, broken down. Every combination you check gets the same three parts.
- 1Plain-English explanationWhat actually happens in your body when the two are combined, written for real people.
- 2A clear next stepAvoid it, space the doses, watch for symptoms, or talk to your prescriber.
- 3The FDA label, quotedThe exact wording from the official label, linked so you can read it yourself.
Higher bleeding risk
SSRI and SNRI antidepressants affect how platelets work. Taken with NSAIDs, aspirin or blood thinners, they raise the risk of bleeding, including stomach bleeding and easy bruising.
Know at a glance what needs attention
Each combination gets one of four levels, based on how strongly the FDA labeling warns about it.
Can cause serious harm
Dangerous sedation, major bleeding or toxic drug levels. Usually a boxed warning or contraindication.
ExampleHydrocodone + GabapentinNeeds precautions
Often used together, but with monitoring, careful timing or a dose change.
ExampleIbuprofen + NaproxenSmall or timing effect
Low impact, usually managed by spacing doses apart or a simple step.
ExamplePepcid + PrilosecNothing listed
Neither FDA label lists the other drug or its class. Reassuring, but not a guarantee.
ExampleIbuprofen + TylenolIn-depth interaction guides
Detailed answers to the combinations people search for most, with who is at risk and what to do.
Ibuprofen + Tylenol
Yes. There is no known interaction between ibuprofen (Advil, Motrin) and acetaminophen (Tylenol). They work in different ways, so doctors often suggest taking them together or alternating them for pain or fever. The real risk is not the combination itself. It is accidentally taking more of either one than the label allows, often through cold, flu or sleep products that contain the same ingredient.
Acetaminophen + Naproxen
Yes. Acetaminophen (Tylenol) and naproxen (Aleve) have no known interaction, and they are often used together for arthritis, back pain, dental pain and injuries. Naproxen lasts much longer than most pain relievers, so acetaminophen can be added in between for extra relief. Be careful with the “PM” versions: Tylenol PM and Aleve PM both contain the sleep aid diphenhydramine, so taking both doubles it.
Sildenafil + Tadalafil
No, not unless a doctor has specifically told you to. Sildenafil (Viagra) and tadalafil (Cialis) are both PDE5 inhibitors that work the same way. The FDA labels say the safety of combining them has not been studied, and doubling up can drop your blood pressure and increase side effects without a proven extra benefit. If one is not working well enough, talk to your prescriber about changing the dose, timing or medicine instead.
Famotidine + Omeprazole
Yes, there is no harmful interaction, and doctors sometimes prescribe them together, for example omeprazole in the morning with famotidine at bedtime for nighttime symptoms. For most people treating heartburn on their own, though, one medicine is enough. If you feel you need both, or need either one for longer than the label allows, it is time to see a doctor.
Ibuprofen + Naproxen
No. Ibuprofen (Advil, Motrin) and naproxen (Aleve) are both NSAIDs, and their labels say not to use them with other NSAIDs. Taking both does not give much extra pain relief, but it does raise the risk of stomach bleeding, ulcers and kidney problems. Pick one. If you need more relief, acetaminophen (Tylenol) can be added because it works differently and does not interact with either.
Ibuprofen + Alcohol
An occasional drink with a normal dose of ibuprofen (Advil, Motrin) is unlikely to cause problems for most healthy adults. But alcohol and ibuprofen both irritate the stomach, and the ibuprofen label warns that having 3 or more alcoholic drinks every day while using it raises the chance of stomach bleeding. Avoid combining them if you drink heavily, have had ulcers, take a blood thinner, or have kidney problems.
Hydrocodone + Gabapentin
Only if your prescriber has planned it and knows you take both. Doctors do sometimes prescribe hydrocodone (Norco, Vicodin) and gabapentin (Neurontin) together for pain, but both slow down the brain and breathing. The gabapentin label warns that using it with opioids has caused serious breathing problems and sedation, sometimes resulting in death. Never start one on your own while taking the other, and never add alcohol or other sedatives.
Metformin + Ozempic
Yes. Metformin and Ozempic (semaglutide) do not have a harmful interaction, and they are one of the most common pairings for type 2 diabetes. Ozempic was studied in people already taking metformin. The main thing to expect is overlapping stomach side effects such as nausea and diarrhea, especially in the first weeks or after a dose increase.
Wellbutrin + Adderall
Sometimes, but only under a prescriber's supervision. Doctors do combine bupropion (Wellbutrin) and Adderall, for example for ADHD with depression. There are two cautions: bupropion lowers the seizure threshold, and stimulants can add to that risk. Bupropion also blocks the liver enzyme CYP2D6, which can raise amphetamine levels in the body.
Three steps, about ten seconds
Add what you take
Brand or generic names, plus pain relievers, sleep aids, supplements and alcohol.
Every pair is checked
Each combination is matched against 80 rules built from FDA labeling, right in your browser.
Read the why and the source
See what happens, what to do, and the exact FDA label wording behind it.
From official label to your answer
Common questions
01Is this drug interaction checker free?
Yes. The checker and every guide on this site are free to use, with no sign-up.
02Where does the interaction information come from?
Every warning is built from official FDA drug labeling, the prescribing information and Drug Facts labels published on DailyMed by the U.S. National Library of Medicine. Each warning shows the label wording it is based on, with a link to the full label.
03What does No known interaction mean?
It means neither FDA label lists the other medicine or its drug class as an interaction, and our rules found no match. It is reassuring, but it is not a guarantee. Your dose, age, health conditions and other medicines still matter.
04Can I use this instead of asking my pharmacist?
No. Use it to prepare better questions. Your pharmacist can see all your prescriptions, doses and health conditions, which a general tool cannot.
05Does the checker store the medicines I enter?
No. The check runs entirely in your browser. The medicines you type are not sent to our server or saved.
This site provides general information for education. It is not medical advice and does not replace your doctor or pharmacist. Never start, stop or change a medicine based on this site alone. In an emergency, call 911 or Poison Control at 1-800-222-1222.
Taking more than one medicine?
Check every combination at once. It takes seconds, and it is free.